Sheffield Wednesday exited the FA Cup on Saturday, going down 3-0 to Premiership outfit Birmingham City at St Andrew's.
Goals from Jean Beausejour, Obafemi Martins and David Murphy did the damage, although the Owls did have moments of their own going forward.
But the Blues had the clinical edge in the final third to progress to round six, leaving Wednesday to concentrate their efforts on climbing the League 1 table.
After a solid start to the cup clash, the visitors saw that promise undone by Brum on six minutes, when Lee Bowyer burst down the left side of the penalty area and cut back for Beausejour to drill past Nicky Weaver.
The Owls responded well, though, and were almost level inside five minutes but Neil Mellor's low effort was deflected wide for a corner.
Play soon reverted to the other end and Keith Fahey forced a fine save from Weaver with a free kick right on the edge of the box.
Weaver was called into action from the next attack, diving low to avert Beausejour's low drive round the post.
Blues enjoyed most of the possession and the second goal that was looming duly arrived on 16 minutes. Martins showed the Owls' defence a clean pair of heels and advanced to slot home in front of the 4,000+ travelling fans from Sheffield.
Birmingham suffered a blow when Alexander Hleb was stretchered off after a mistimed tackle by James O'Connor, before the Owls made a change when Richard Hinds came on for Mark Reynolds.
Cameron Jerome went close for the home side as half time approached but Wednesday also threatened when Michael Morrison's shot from ten yards was blocked by Stephen Carrr.
The Owls came closer still just before the break. Daniel Jones did well to shake off the attention of Stephen Carr and slide a low cross across the danger zone but the ball just evaded the loitering Mellor.
Wednesday made two more changes for the second half, with Michael Morrison and O'Connor making way for Mark Beevers and Liam Palmer.
But the pendulum stayed the way of Birmingham, who extended their lead on 52 minutes. A curling corner from the right fell kindly to Murphy to hit high into the net from close range and effectively put Birmingham out of reach.
Martins could and should have made it four moments later but clipped over the bar following good work from substitute David Bentley.
Wednesday rallied and enjoyed pockets of possession as the remainder of the game unfolded but couldn't breach the Blues' backline and the contest petered out with Birmingham's route to the quarter finals safely secure.
Birmingham: Doyle, Murphy, Johnson (Mutch 63), Carr, Parnaby, Hleb (Bentley 26), Beausejour, Fahey, Bowyer, Jerome (Phillips 46), Martins
Unused substitutes: Foster, Larsson, Gardner, Zigic
Owls: Weaver, Spurr, R Johnson, M Morrison (Beevers 46), Reynolds (Hinds 28), Jones, Osbourne, O'Connor (Palmer 46), Teale, Morrison, Mellor
Unused substitutes: Jameson, Sedgwick, Potter, Heffernan