The Owls came from behind to secure an impressive away win at Tranmere on Saturday.
Jose Baxter gave Rovers a first half lead before Chris Lines equalised just before the break.
But substitute Ryan Lowe struck with ten minutes to go to ensure Wednesday keep the heat on Charlton and Huddersfield in the two automatic promotion places in League 1.
Gary Megson was forced to shuffle his pack as hamstring victim Lewis Buxton gave way to Liam Palmer, who was fresh from Under-21 international duty with Scotland.
Elsewhere, Stephen Bywater resumed between the sticks in place of Richard O'Donnell and Reda Johnson came in at left back for Julian Bennett.
After a scrappy start to the contest, the hosts came close to opening the scoring when the lively Baxter tried a long range dipping effort that had just too much purchase to land beneath the crossbar.
Rovers threatened again 20 minutes in, with Mustafa Tiryaki heading over when the striker might have done better from skipper John Welsh's cross.
For their part, the Owls saw plenty of the ball but struggled to make an impression beyond the engine room.
The better chances of the half fell to Tranmere and the ball was in the net on the half-hour mark when Baxter headed home from six yards but the goal was chalked off by the linesman's raised flag.
The 2,000-strong travelling contingent from Sheffield had to wait until the latter stages of the first 45 to see their side muster a shot on target.
James O'Connor linked up well with Chris O'Grady, who neatly set up Lines but the midfielder's shot was comfortably collected by Owain Fon Williams.
Eight minutes before the break, Rovers struck the goal that gave Les Parry's side a deserved lead.
Baxter picked up possession just outside the penalty area and a clever dummy gave the popular midfield man the time and space to pick his slot past Bywater.
But just as Tranmere seemed to be heading down the tunnel in the ascendancy, Wednesday struck out of the blue on the stroke of half time.
Ben Marshall's long throw caused a melee in the box and the ball fell kindly to Lines, who struck hard and low from 18 yards to claim his second strike in as many games to level the score.
Lowe replaced Gary Madine for the start of the second period but it was man of the moment Lines who came close to taking the plaudits with a wonderful half volley that fizzed narrowly over the crossbar.
Palmer also went close minutes later, beating two players before unleashing a fierce drive that beat Fon Williams but also the upright.
It was much better from Wednesday as the second 45 unfolded - the spark that was lacking in the first half reappeared and Rovers were on the back foot.
Marshall began to assert his authority on the game and the Tranmere defence struggled to combat the livewire loanee.
Only some stout defending on the back post by David Buchanan prevented Lowe notching after trademark trickery down the left from Marshall.
Tranmere responded with Andy Robinson bringing a fine save out of Bywater before Baxter should have restored the Merseysiders' lead but his angled side-footer fell the wrong side of the post.
O'Grady had a chance moments later at the other end but lofted over the bar before Fon Williams thwarted Lowe with a fine near post save.
But Lowe was not to be denied and the prolific frontman settled the game ten minutes from time.
Marshall's cross was headed back across by Johnson and Lowe was right on the spot three yards out to head into an empty net and hand the Owls a valuable victory.
Tranmere: Fon Williams, Goodison, Welsh, Tiryaki (McGurk 68), Weir (Labadie 85), Robinson (Devaney 82), Taylor, Buchanan, Akins, Raven, Baxter
Unused substitutes: McChrystal, Coughlin
Owls: Bywater, Palmer, Batth, R Jones, R Johnson, Marshall (Bennett 87) Semedo, O'Connor, Lines, Madine (Lowe 46), O'Grady
Unused substitutes: O'Donnell, Prutton, Morrison