Sheffield Wednesday struck an injury-time winner to beat Carlisle 2-1 on a dramatic afternoon at Hillsborough.
Chris Lines had earlier given the Owls the advantage in a game the home side controlled from the first whistle.
Dave Jones' side completely dominated and on another day would have added significantly to their tally but James Berrett struck with seven minutes to go.
But Antonio sealed three vital points right at the last with a superb strike to strengthen the Owls' promotion credentials.
Wednesday started the key contest brightly, with Antonio posing a regular threat down the right flank.
Time and again, the Reading loanee charged down the wing before sending dangerous balls into the box, with one resulting effort from Mark Beevers brushing the top of the net.
Lewis Buxton also caused Carlisle problems on the overlap, while on the other side of the pitch, Jermaine Johnson grew into the game as the first half unfolded.
But it was Antonio at the heart of the action and his long throw on 23 minutes found the onrushing Danny Batth, who sent in a powerful header that Adam Collin acrobatically tipped over the crossbar.
And one minute later, Wednesday were in front. Johnson forced a fine save from Collin after bursting into the box and Lines was on hand to tap into the back of the net following the goalkeeper's parry.
The lead was fully deserved and a reflection of the Owls' dominance as the visitors struggled to contain their hosts' attacking prowess.
Stephen Bywater was virtually a bystander as Wednesday continued to press and they almost doubled their lead 12 minutes before the break when Nile Ranger drilled a half volley goalwards but Collin again came to the rescue with a diving save.
Johnson then hared in on goal and Collin narrowed the angle well to save and Beevers brought another fine stop from the Carlisle custodian as Wednesday went down the tunnel squarely in the box seat.
More of the same was the order of the day for the Owls in the second half and six minutes in, they came close to a second after Lines delivered a floating cross to the back post and Antonio's header beat Collin only for Lubomir Michalik to clear off the line.
Ranger then did well to dispossess ex-Owl Frank Simek and cut inside before testing Collin with a low drive.
Keith Treacy was introduced for Johnson and his long punt upfield on the hour was chased down by Antonio, who went to ground following a tangle with Danny Livesey but the referee waved away Wednesday claims for a free kick.
Former Carlisle man Gary Madine fired over the bar before Carlisle carved a rare opportunity that Francois Zoko blasted over the crossbar.
Then with just seven minutes to go, the Cumbrians stunned the home crowd with a goal out of the blue.
The Wednesday wall beat down a set piece from 25 yards and the ball fell to Berrett to drive a fierce shot home from the edge of the area.
Just as it seemed the visitors had broken S6 hearts, Antonio popped in time added on to blast an unstoppable shot from the left across Collin and into the back of the Kop net.
Owls: Bywater, Buxton, Batth, Llera, Beevers, Antonio (Prutton 90), Semedo, Lines, J Johnson (Treacy 57), Madine, Ranger
Unused substitutes: Weaver, R Jones, Lowe
Carlisle: Collin, Simek, Livesey, Murphy (Robson 46), Madden (McGovern 74), Taiwo (Welsh 74), Zoko, Cook, Noble, Berrett, Michalik
Unused substitutes: Thirlwell, Beck