Own goals at either end ensured the Owls and MK Dons each earned a share of the spoils from this top of the table League 1 clash.
Stephen Bywater and Gary MacKenzie were the fall guys, which typified a game where chances came at a premium.
Indeed, neither goalkeeper was forced into a significant save as a stop-start encounter finished all square at Stadium:mk.
It was all change once more for the Owls, who made seven changes following the weekend draw at Blackpool in the FA Cup.
New loan recruit John Bostock began his S6 stint on the bench, while Gary Madine and Chris O'Grady - two-goal hero at Scunthorpe seven days ago - returned to the starting line-up in the final third.
The early exchanges saw both sides tentatively feel each other out, with the only effort on goal a tame long range effort from Dean Bowditch.
But right on the 15-minute mark, the game suddenly came to life as the Dons struck first blood.
There seemed little on for Luke Chadwick 22 yards out but the former Manchester United midfielder let fly and the ball landed in the back of Bywater's net having struck the unfortunate keeper via the underside of the crossbar.
Madine saw a handball appeal in the home team's penalty area waved away as the Owls sought an immediate response.
And on 27 minutes, Wednesday did draw level and again it was an own goal that balanced the scales.
Chris Sedgwick did well down the left flank to hook a dangerous ball into the mix and, with three Owls players rushing in, MacKenzie inadvertently put past his own keeper David Martin.
Half time came and went with little between the two promotion contenders but Wednesday began the second period in the ascendency.
Reda Johnson went close with two headers inside a minute before David Prutton drilled a fierce shot wide from distance.
But still any clear cut opportunities were lacking and Gary Megson introduced Jermaine Johnson in a bid to find an attacking spark with half an hour to go.
One trademark run and shot almost had the desired effect and the pace ace then aimed a good cross to O'Grady, whose header flew just over the bar.
But there was to be no further way through for Wednesday, who nonetheless drew level pegging once more with Huddersfield in second place with this hard-fought and valuable point.
MK Dons: Martin, Lewington, MacKenzie, Gleeson, Bowditch, MacDonald (Ibehre 62), Chicksen (Smith 51), Williams, Flanagan, O'Shea (Powell 80), Chadwick
Unused substitutes: McLoughlin, Baldock
Wednesday: Bywater, Otsemobor, Batth, Llera, R Johnson, Buxton, Sedgwick (Bostock 61), Prutton, Semedo, Madine (J Johnson 62), O'Grady (Morrison 83)
Unused substitutes: Weaver, Lines