In the previous meeting at St Andrew’s this season, Birmingham inflicted a heavy defeat on Wednesday but the Owls returned the favour at Hillsborough on Saturday.
Wednesday added three points to the board with a comfortable 4-1 win over the Blues.
Caolan Lavery was the man of the moment, scoring twice with goals also coming from Leon Best and a Will Packwood own goal.
Lee Novak did pull one back for the Blues but that did little to influence the outcome of a game that the Owls largely controlled from the off.
Stuart Gray rang the changes, with Chris Maguire, Kieran Lee, Sam Hutchinson and Atdhe Nuhiu all back in the starting 11.
Wednesday were first to threaten in the contest with a low Maguire free kick well gathered by Darren Randolph.
But there was little the former Motherwell goalkeeper could do to prevent the Owls’ opener on 16 minutes.
Lavery advanced down the right before tricking his marker with a neat cut back and drilling into the bottom corner of the Kop net.
The Northern Ireland Under-21 was at the heart of the action moments later as Wednesday struck again to stun the Blues.
Maguire’s corner was flicked goalwards by Lavery and Best was left with the easiest of tasks to knock into the net on the goal line.
Rocked by the early setback, Blues boss Lee Clark made an early change with left back Tyler Blackett making way for Paul Caddis.
The visitors’ first sign of intent came midway through the first period when Novak broke clear on the counter but Glenn Loovens made a superb recovery challenge to stop the ex-Huddersfield man in his tracks.
Then on the stroke of the whistle, Nuhiu slammed home into the net from six yards from a low Lewis Buxton centre, but the referee ruled out the strike for an infringement from the big striker.
It was proving a tough old afternoon for Birmingham that was made worse just before the hour when the unfortunate Packwood diverted past his own goalkeeper.
After a pacy piece of wing play by Jeremy Helan, the Frenchman fizzed a low cross into the box and as Packwood stuck out a leg to intercept, the ball looped up over Randolph and into the net.
Birmingham’s luck was out on that occasion but Wednesday were in no mood to relent as Lavery thumped home his second of the game.
Maguire teed up the 21-year-old, who took aim and slammed into the top corner – undoubtedly the goal of the game.
With the points all but wrapped up for the hosts, Birmingham notched a consolation when Federico Macheda fired across goal with Novak lurking in the centre to convert.
But Wednesday remained comfortable as the clock ticked down to make a return to winning ways.
Owls: Martinez, Buxton, Loovens (Llera 75), Onyewu, Helan, Hutchinson, Lee, Maguire (Afobe 69), Lavery (J Johnson 80), Nuhiu, Best
Birmingham: Randolph, Robinson (Martin 46), Burke, Novak, Packwood, Lee (Macheda 55), Shinnie, Spector, Adeyemi, Huws, Blackett (Caddis 24)