It’s FA Cup fourth round weekend and for Wednesday, a trip to holders Chelsea.
Following a goalless draw against Luton in round three at Hillsborough, the Owls triumphed in the replay 1-0 at Kenilworth Road with Atdhe Nuhiu on target.
In all competitions, Wednesday head into the game with just one defeat in eight.
Chelsea continue their defence of the cup on Sunday after overcoming Nottingham Forest 2-0 in the previous round on home soil.
The Blues lifted the famous trophy back in May when they defeated Manchester United 1-0 at Wembley.
Maurizio Sarri’s side are fourth in the Premier League and made it into the final of the Carabao Cup earlier this week with victory over rivals Tottenham on penalties following a 2-2 aggregate scoreline.
Owls: Fernando Forestieri is likely to be included in the squad after working his way back to fitness from a hamstring injury.
Loanee Michael Hector will miss out against his parent club.
Elsewhere, Josh Onomah (hamstring) is a week away from his return while Matt Penney (shoulder) is expected to be sidelined until April.
Otherwise, there are no fresh injury concerns from the Owls' 1-0 win over Wigan last time out.
Chelsea: Head coach Sarri is likely to rotate his squad after Thursday’s Carabao Cup semi final victory over Spurs.
Sarri will assess the fitness of new signing Gonzalo Higuain and Ruben Loftus-Cheek, who is back in training after a back injury.
Higuain, who could make his Chelsea debut against the Owls, joined the Blues on loan from Juventus earlier this week with an option to buy.
The former Real Madrid striker reunites with Sarri, who was head coach at Napoli when Higuaín equalled the all-time Serie A scoring record for a single season, with 36 goals in 2015/16.
Pre-match interview - Sam Hutchinson
The Owls’ allocation of 5,917 at Stamford Bridge is a sell-out for the 6.00pm kick-off.
Information for travelling supporters
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Follow the game live
We’ll have online live match commentary on iFollow from 5.30pm.
Due to broadcast restrictions, the game will not be streamed on iFollow.
The cup clash will be live on BBC1.
Last five v Chelsea
Owls 1-0 Chelsea | 15 April 2000 | Premier League (pictured)
Chelsea 3-0 Owls | 29 December 1999 | Premier League
Owls 0-0 Chelsea | 25 April 1999 | Premier League
Owls 0-1 Chelsea | 13 February 1999 | FA Cup
Chelsea 1-1 Owls | 28 November 1998 | Premier League