The Owls will be looking to maintain their unbeaten league run on home soil under manager Garry Monk this weekend.
Wednesday are unbeaten in six at Hillsborough under Monk.
In-form Brentford are the opposition, who have won six of their last eight league games, including last Saturday’s remarkable 7-0 win over Luton.
Wednesday returned to winning ways last week at Charlton with a double from top scorer Steven Fletcher and a goal from Atdhe Nuhiu.
Heading into the game, just one point separates the two sides, with Brentford (30 points) in seventh spot, one point shy of the play-off places and the Owls (29 points) just behind.
SWFC: Fernando Forestieri (knee) is unlikely to feature against the Bees.
The Wednesday forward picked up a knock during the first half in last week’s win at The Valley and is expected to be sidelined for 7-10 days.
Julian Börner is available for selection after completing his one-match suspension.
Liam Palmer serves the final game of his three-match ban.
Elsewhere, there are no fresh injuries for the Owls.
Brentford: Winger Sergi Canos (knee) is closing in on a first team return but the trip to Hillsborough may come too soon for the Spaniard.
The other notable injury absentee for the Bees is striker Nikos Karelis (also knee), who is sidelined for a number of months.
It is unlikely the Bees will make any changes to the side that beat Luton so convincingly.
Tickets for this Category E fixture start from £25 for Adult Owls Members and £5 for under 11 Members on the Kop.
Owls fans are advised that the 1867 Lounge will be closed after half time due to a Christmas function in the evening.
Sheffield Wednesday are reminding supporters of their conduct whilst following the team both at Hillsborough and away from home.
The launching of missiles from the stands, including pyrotechnics, are criminal offences and the club have a zero-tolerance policy to these.
Due to broadcast restrictions, the game will not be available on iFollow for overseas subscribers to stream.
The fixture has been selected as the Pitch International overseas broadcast.
Live match commentary will be provided by Rob O’Neill and John Pearson.
Last five v Brentford
Owls 2-0 Brentford – 26 February 2019 – Championship (pictured above)
Brentford 2-0 Owls – 19 August 2018 – Championship
Brentford 2-0 Owls – 30 December 2017 – Championship
Owls 2-1 Brentford – 12 September 2017 – Championship
Owls 1-2 Brentford – 21 February 2017 – Championship