The Owls Under-21s lost 2-1 to Wigan Athletic at Middlewood Road on Saturday.
Wednesday dictated the run of play yet could not provide the finishing touches in the final third.
Jarrod Kyle did convert for the home side but his strike was not enough to prevent a narrow defeat.
In a game of few chances, Caolan Lavery tested the visiting goalkeeper on 25 minutes before, against the run of play, Wigan scored just after the half-hour.
But the Owls replied with a goal of their own three minutes before half time.
Taylor McKenzie’s precise through-ball found Matt Fletcher in the penalty box and his shot was parried clear, but only into the path of Kyle, who coolly fired home.
Wigan came out strong after the break and had a goal ruled out for offside before regaining the advantage on 66 minutes with a strike that ultimately won the game.
Owls coach Lee Bullen said: “Overall, I was really pleased with a lot of aspects of our play. We tried to play football, tried to play out of the back.
“But I’m very frustrated with the goals we lost to individual errors. To be fair, the goal we got was from an individual error, so three individual errors caused the goals.
“The nuts and bolts of football is in the final third, and that’s where a little bit of confidence or brilliance, or a mistake, can make a difference.”
Owls: Davies, Lee, McKenzie, Nyoni (Peacock 14), Balugon, Hery, Hinchliffe (Sellars 76), Grant, Fletcher, Lavery (Rudonja 86), Kyle