The Owls’ Under-21s beat local rivals Sheffield United 3-2 at Hillsborough on Tuesday night.
A Gary Madine double in the first half put Wednesday in the driving seat before Danny Philliskirk pulled one back after the break.
Lee Bullen’s side effectively sealed the win late on with Rodri finding the net and Philliskirk scored again at the death but it was too little too late for the Blades.
After a bright start, the Owls took the lead on nine minutes when, following some excellent work down the middle from Danny Mayor, Madine broke free down the right side of the penalty area and finished coolly past the advancing George Willis.
Possession then evened out and both sides had half chances in an entertaining derby encounter.
The game was nicely poised with half time approaching but Wednesday took a significant stride towards maximum points on 38 minutes.
The lively Caolon Lavery burst down the right channel and looked up before squaring to Madine, who slammed into the roof of the net from close range.
The Blades came out fighting after the break and Shaun Miller forced a fine save from Arron Jameson before the visitors halved the arrears on 55 minutes when Philliskirk swept into the top corner after some neat footwork from Miller.
But just as it seemed United were getting a foothold back into the game, Mayor danced into the penalty area on 75 minutes and evaded two challenges to feed Rodri, who fired home to put the result beyond doubt.
Still there was time for some late drama when Lavery skied a penalty into the Kop after substitute Harry Grant was felled in the area by Willis, before almost on the final whistle, Philliskirk netted to give the scoreline a more balanced look.