The Owls Under-21s’ Premier League Cup game against Leicester will be played at Loughborough University on Tuesday 19 November.
The tie was originally scheduled for King Power Stadium but will now take place at Loughborough.
The cup clash will kick off at 7.00pm and Owls supporters are welcome to attend, with entrance priced at £3 and £1 concessions.
Wednesday progressed to the second round of the inaugural competition after beating Huddersfield in round one last month.