The Owls are on home soil in the Championship for the first time this season as Derby visit Hillsborough.
Wednesday are out to build on last week’s impressive win at Brighton, while the Rams also kicked off with victory, against Rotherham at the iPro Stadium.
New recruit Stevie May debuts for the Owls following his recent move from SPL side St Johnstone.
Owls: Westwood, Palmer, Loovens, Lees, Mattock, Maguire, Lee, Hutchinson, Maghoma, Nuhiu, May
Substitutes: Kirkland, Zayatte, Semedo, Coke, Helan, McCabe, Madine
Derby: Grant, Christie, Forsyth, Bryson, Buxton, Keogh, Dawkins, Hendrick, Martin, Ward, Hughes,
Substitutes: Roos, Naylor, Eustace, Whitbread, Best, Russell, Mascarell
If you cannot make the game, listen to EXCLUSIVE live commentary on Wednesday Player