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Owls: Strikers Connor Wickham and Caolan Lavery are both unavailable for selection.
Wickham will not feature in the cup clash under the terms of his loan agreement from Sunderland.
As Lavery, who was on loan with League 2 side Plymouth, was unavailable for selection in the original cup-tie at Moss Rose, the 21-year-old is not permitted to feature in the replay.
Stuart Gray has confirmed that Damian Martinez will start between the sticks for Wednesday.
Macclesfield: Manager John Askey should have a full squad to select from with no new injury concerns from the first leg at Moss Rose.
The Silkmen are unbeaten in five games and earned a replay at Hillsborough after drawing 1-1 on home soil, with Steve Williams equalising for Macclesfield after Reda Johnson had given the Owls the lead.
Last time out - Owls 6-0 Leeds
4 January 2014
Macclesfield 1-1 Owls
(Williams 72; R Johnson 25)
Head to head
One to watch – Dan Whitaker
The former Oldham and Chesterfield man caught the eye in the clash at Moss Rose nine days ago.
The tricky winger is in his second spell with Macclesfield after leaving the club in 2006, when he left to join Port Vale.