Owls striker Stevie May is fully fit and ready to battle on both the domestic and international fronts.
The hitman had been struck down with a virus and as a result, was on the bench for the Owls’ two previous outings.
But it has been a positive week for the former St Johnstone man, who has fully recovered from illness and received another call-up to the Scotland squad.
Owls head coach Stuart Gray said: “Stevie May is fully fit, he has got over his virus and trained fully all week.
“It’s a big opportunity for him on Saturday on the back of being called up for Scotland.”
The striker’s services were also sought after by Rotherham manager Steve Evans prior to May’s arrival at Hillsborough.
The Millers boss was disappointed not to land his man and believes Wednesday have a bright young forward on their hands.
He said: “I think he arrived in Rotherham that morning at about 11.30 and he was still with me at six o’clock at night before we set off for Derby County.
“What happened doesn’t take away my admiration for a young man who I think highly of. But listen, would I have done the same to Stuart? Absolutely. Football is a ruthless business.
“We tried desperately to get him in, and time will prove Stuart signed an excellent player in Stevie May.”