Carlos Carvalhal gave credit to Burton on Tuesday and said his injury-hit backline felt the brunt during his side’s 3-1 defeat.
Already missing regulars Glenn Loovens and Tom Lees, the Owls suffered a further blow when stand-in centre half Jose Semedo was withdrawn on the stroke of half time with a muscle strain.
Earlier, Kyle McFadzean opened the scoring for the home side, but they were pegged back when Gary Hooper converted a penalty for Wednesday.
Moments after Semedo was forced off, Burton took full advantage when Jackson Irvine’s header put the Brewers back in front.
Lloyd Dyer’s goal on 77 minutes sealed the 3-1 win.
Carvalhal said: “First of all, congratulations to Burton.
“They have a certain style, they got the ball long up the pitch and it worked very well for them.
“We lost some co-ordination when we lost Semedo just before half time, the defence had to re-organise very quickly and Burton took advantage of our weaknesses."
Lees was ruled out through injury before the match but Carvalhal is hopeful the former Leeds man will be back in time for Saturday’s game against his former employers.
He added: “When Tom can’t play you know he is feeling pain because he always wants to play.
“He couldn’t play today because he received a bad kick against Norwich but I think he should be okay for Saturday.”