The Owls head to the Midlands to face a Birmingham side seeking a route from the bottom three, while the visitors are out to post a swift response following defeat in the Steel City derby on Sunday.
Birmingham: Kuszczak, Nsue, Colin, Gardner, Jutkiewicz, Dean, Ndoye, Maghoma, Boga, Davis, Morrison
Substitutes: Trueman, Grounds, Roberts, Vassell, Gallagher, Cotterill, Gleeson
Wednesday: Wildsmith, Hunt, Lees, van Aken, Fox, Reach, Bannan, Lee, Butterfield, Fletcher, Hooper
Substitutes: Dawson, Pudil, Palmer, Jones, Wallace, Joao, Rhodes