The Owls take on Brentford at Hillsborough looking to build on their 3-1 victory over Nottingham Forest at the weekend, with the Bees hoping to get their first three points of the campaign.
Wednesday: Westwood, Hunt, Lees, van Aken, Reach, Wallace, Lee, Jones, Bannan, Fletcher, Hooper
Substitutes: Wildsmith, Palmer, Pudil, Matias, Butterfield, Rhodes, Joao
Brentford: Bentley, Henry, Yennaris, Maupay, Watkins, Egan, Woods, Sawyers, Clarke, Dalsgaard, Barbet
Substitutes: Daniels, Bjelland, Jozefzoon, McEachran, Mokotjo, Shaibu, Chatzitheodoridis