The Owls travel to the Riverside Stadium hoping to build on a positive result in the FA Cup on Friday against Reading, with Middlesbrough looking for a fourth win in five in all competitions.
Middlesbrough: Randolph, Friend, Ayala, Shotton, Gibson, Leadbitter, Assombalonga, Bamford, Howson, Downing, Troare
Substitutes: Dimi, Clayton, Braithwaite, Fletcher, Fry, Christie, Gestede
Wednesday: Wildsmith, Palmer, Venancio, Pudil, Thorniley, Fox, Wallace, Pelupessy, Butterfield, Reach, Joao
Substitutes: Dawson, Hunt, Jones, Rhodes, Nuhiu, Boyd, Nielsen