The Owls’ Under-23s suffered a comprehensive defeat against an experienced Birmingham side that catapulted to the top of the PDL North table.
The hosts triumphed 4-0 on a bleak afternoon for Wednesday, who finished the game with ten men having made all their substitutions before losing Isaac Rice to injury.
Then Kyle Hurst doubled the lead with a close range finish in first half stoppage time to give the Owls an uphill battle after the break.
And when Olly McCoy made it 3-0, calmly ending a swift counter on 64 minutes, it was all but over for Wednesday.
Tommy Anderson completed the scoring with five minutes to go following a knock to Rice and the Owls travelled back from the Midlands well beaten by the Blues.
Wednesday: McCulloch, Dawodu (Clarke 75), Hughes, Shaw, O’Grady, Rice, Preston, Waldock (Grant 65), Stobbs, Kirby, Boyd (Borukov 46)