The Owls Under-18s will be aiming for a return to winning ways on Saturday at Middlewood Road.
Wednesday, who are third and one point below joint leaders Leeds and Nottingham Forest, host a Birmingham side sixth in the division.
Andy Holdsworth’s side have drawn their previous two outings against Burnley and Barnsley, with both games finishing 2-2.
The Blues come into the game in good form with back to back wins over Bristol City and leaders Forest.
Kick-off on Saturday is at 1.00pm and supporters are welcome to attend the fixture.