The Owls will face Walsall at the Banks’ Stadium in the first round of the Carabao Cup.
The fixture is scheduled to take place on Saturday 5 September, kicking off Wednesday’s 2020/21 competitive fixtures.
Wednesday last faced the Saddlers in League One, during the Owls' 2011/12 promotion season.
The fixture, in March 2012 at Hillsborough, saw goals from Ryan Lowe and Gary Madine contribute to a 2-2 draw.