The Owls host Reading and are unchanged from the goalless draw with Stoke on Saturday, while the Royals arrive at Hillsborough looking to climb back into play-off contention.
Wednesday: Wildsmith, Palmer, Borner, Lees, van Aken, Reach, Bannan, Luongo, Shaw, Harris, Paterson
Substitutes: Dawson, Odubajo, Penney, Dele-Bashiru, Iorfa, Brown, Pelupessy, Kachunga, Rhodes
Reading: Cabral, Richards, Morrison, Moore, Olise, Rinomhota, Ejaria, Joao, Laurent, Holmes, Semedo
Substitutes: Walker, Eteves, McIntyre, Baldock, Gibson, Aluko, Tetek, Watson, Onen