Wednesday head to Kenilworth Road this evening after back to back draws with Millwall and Barnsley.
The Owls will be aiming to bring an end to their four-game winless run in the Championship.
Luton, meanwhile, have just one win from their last 12 outings but know a victory this evening would see the Hatters rise from the foot of the division.
Wednesday’s last league win at Kenilworth Road came way back in March 1989 but the Owls did triumph 1-0 last season in the FA Cup replay, with Atdhe Nuhiu scoring the game’s only goal.
SWFC: Garry Monk is hopeful to have Owls duo Morgan Fox (ankle) and Massimo Luongo (groin) available for the Luton clash.
Moses Odubajo (hamstring) and Adam Reach (toe) will be assessed ahead of the game.
Luton: The Hatters are likely to be unchanged from the weekend 1-0 home defeat to Cardiff.
The only question for manager Graeme Jones is the fitness of Izzy Brown, who was substituted on Saturday on the hour as a precaution after picking up a knock.
Current form in all competitions
Steven Fletcher: 12 goals
James Collins: 9 goals
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Sheffield Wednesday are reminding supporters of their conduct whilst following the team both at Hillsborough and away from home.
The launching of missiles from the stands, including pyrotechnics, are criminal offences to which the club has a zero tolerance policy.
Offensive or unlawful chanting could result in ejection from the stadium and further action from the club and/or relevant authorities.
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Last meeting – 20 August 2019
Last five v Luton
Owls 1-0 Luton - 20 August 2019 - Championship
Luton 0-1 Owls - 15 January 2019 – FA Cup
Owls 0-0 Luton - 5 January 2019 – FA Cup
Luton 3-2 Owls - 20 February 2007 – Championship
Owls 0-1 Luton - 8 August 2006 – Championship