The Owls will be aiming to build on their midweek victory over Charlton at Hillsborough.
Wednesday’s winless run in the Championship came to an end after Steven Fletcher struck late against the Addicks to seal three points.
The Rams arrive at Hillsborough on the back of a 2-1 defeat away at QPR on Tuesday.
Phillip Cocu’s side are now on a four-game winless run after enjoying a good spell of form since Christmas.
Derby have struggled on the road this season with just two wins from 17 games.
SWFC: Adam Reach, Moses Odubajo and Massimo Luongo are expected to return to training next week.
Garry Monk has not ruled out the possibility of starting Steven Fletcher on Saturday.
The striker was back on the scoresheet in midweek and, although still building up his fitness after a period on the sidelines, could be named in the starting XI this weekend.
Elsewhere there are no fresh injury concerns for Wednesday.
Derby: Duane Holmes (ankle) continues with his recovery.
Long-term absentees Ikechi Anya (calf) and Krystian Bielik (knee) remain sidelined.
Tom Huddlestone (hamstring) will not feature at Hillsborough.
Current form in all competitions
Steven Fletcher: 13 goals
Martyn Waghorn: 12 goals
Leading Championship appearances
Barry Bannan: 33 appearances
Martyn Waghorn: 35 appearances
Most recent line-ups
Wednesday v Charlton (1-0): Dawson, Palmer, Lees, Börner, Fox, Lee, Bannan, Harris (Fletcher 57), Murphy, Forestieri (Da Cruz 79), Wickham (Nuhiu 75)
QPR v Derby (2-1): Hamer, Davies (Bogle 71), Lowe, Clarke, Wisdom, Rooney, Lawrence, Waghorn, Shinnie (Whittaker 79), Bird, Marriott (Martin 72)
Tickets for this Category C fixture start from £31 for Adult Owls Members and £5 for Under 11 Members on the Kop.
Sheffield Wednesday are reminding supporters of their conduct whilst following the team both at Hillsborough and away from home.
The launching of missiles from the stands, including pyrotechnics, are criminal offences to which the club has a zero tolerance policy.
Offensive or unlawful chanting could result in ejection from the stadium and further action from the club and/or relevant authorities.
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Last meeting – 11 December 2019
Last five v Charlton
Derby 1-1 Owls - 11 December 2019 - Championship
Derby 1-1 Owls - 9 March 2019 – Championship
Owls 1-2 Derby - 24 November 2018 – Championship
Owls 2-0 Derby - 13 February 2018 – Championship
Derby 2-0 Owls – 21 October 2017 – Championship