The Owls face Brentford at Griffin Park for the final time ahead of the Bees’ move to their new stadium next season.
Wednesday make four changes to the side that faced Manchester City in midweek, with Cameron Dawson, Tom Lees, Josh Windass and Steven Fletcher coming into the starting eleven.
Brentford: Raya, Henry, Pinnock, Norgaard, Benrahma, Watkins, Dasilva, Marcodes, Mbeumo, Dalsgaard, Jeanvier
Substitutes: Daniels, Valencia, Dervisoglu, Fosu, Baptiste, Racic, Roerslev
Wednesday: Dawson, Palmer, Lees, Iorfa, Fox, Murphy, Bannan, Pelupessy, Windass, Da Cruz, Fletcher
Substitutes: Wildsmith, Urhoghide, Hunt, Harris, Forestieri, Wickham, Nuhiu