The Owls make a short trip to the New York Stadium to face South Yorkshire rivals Rotherham.
Darren Moore makes five changes to the Owls side that beat Fleetwood on Tuesday, with Chey Dunkley, Jaden Brown, Massimo Luongo, Callum Paterson and Florian Kamberi all starting.
Rotherham: Johansson, Harding, Wood, Wiles, Ogbene, Lindsay, Ferguson, Rathbone, Kayode, Ihiekwe, Smith
Substitutes: Vickers, Mattock, Barlaser, Sadlier, Ladapo, Miller, Edmonds-Green
Wednesday: Peacock-Farrell, Palmer, Iorfa, Dunkley, Hunt, Luongo, Wing, Bannan, Brown, Paterson, Kamberi
Substitutes: Wildsmith, Adeniran, Byers, Dele-Bashiru, Johnson, Corbeanu, Gregory