Wednesday were edged out of this top of the table clash as Wycombe triumphed 1-0 thanks to Jordan Obita’s second half goal.
A tight affair was predicted at Adams Park and duly unfolded, with both sides struggling to fashion clear cut chances.
The best of the lot fell to Obita and the frontman made no mistake to put a dent in the Owls’ promotion ambitions with two games left to play.
With the stakes so high, moments of quality were few during the early exchanges, which the visitors certainly shaded.
Massimo Luongo sent an early sighter wide, Nathaniel Mendez-Laing was inches away from range and Chey Dunkley did find the net only to see a raised flag cut short the celebrations.
The hosts began to grow into the game as the first half unfolded - Sam Vokes forced a diving save from Bailey Peacock-Farrell and Garath McCleary fired over the top.
Wednesday put themselves into a raft of promising positions only to be let down by the final ball, from open play and set pieces.
But overall, Darren Moore’s men enjoyed the better moments in an opening period relatively free of real talking points.
It was more of the same after the break, with the Owls seeing plenty of the ball without threatening the Chairboys backline.
Daryl Horgan tried his luck from distance and was off target before the referee waved away a penalty appeal when Jason McCarthy blocked a Marvin Johnson effort inside the box.
But out of nowhere, Wycombe scored the decisive goal on 62 minutes. Horgan burst into the penalty area down the right and looked up to pick out Obita, who calmly stroked home from six yards.
Back came Wednesday and Dunkley scooped a Barry Bannan corner over but for all their endevour, the Owls could not find a way through the hosts’ resolute rearguard.
Bannan stood one up for substitute Callum Paterson at the back post but the Scot’s header was too high, leaving the Owls with plenty to do to claim one of those coveted top-six slots.
Wednesday: Peacock-Farrell, Mendez-Laing, Storey, Dunkley, Hutchinson, Johnson, Luongo, Dele-Bashiru (Paterson 77), Bannan, Berahino (Shodipo 68), Gregory