The Owls will host Barnsley in the third round of the FA Youth Cup on Wednesday 30 November.
Once again, the cup-tie will be staged at Hillsborough and kick off at 7:00pm.
Wednesday produced an excellent performance against Derby on Monday night to advance into round three.
Sean Fusire’s second half goal was enough to down the Rams in S6.
Barnsley inflicted a 2-1 defeat on Scunthorpe at Oakwell to reach round three.
The Owls and the Reds met in the Under-18 Professional Development League last month and played out a close-fought goalless draw at Oakwell Training Ground.