The Owls will host National League South side Hemel Hempstead in the third round of the FA Youth Cup at Hillsborough on Saturday 9 December (12 noon kick-off).
The Tudors are in the third round stage of the prestigious competition for the first time in the club’s history after thumping League One Exeter 5-2 at the Focus Community Arena.
Prior to that, Hemel Hempstead beat Takeley in round one after overcoming Wingate & Finchley, Southend and Brentwood Town in the qualifying stages.
Wednesday reached round five last season, going out at Cambridge following home wins over Burton, Derby Barnsley and Leicester.
Entrance to the S6 cup-tie is free to Season Ticket holders, with match tickets priced £3 for adults and £1 concessions.
The Owls were due to face Sheffield United on Saturday and this game has now been rearranged for Tuesday 7 May (2:00pm).